Burutselyoz kasalligi patogenezi va labarator diagnostik tahlili
Kalit so'zlar:
Brutsellyoz, Brucella, zoonoz infeksiya, makrofag, granuloma, serologik testlar, ELISA, PCR, surunkali yallig‗lanishAnnotatsiya
Brutsellyoz — Brucella jinsiga mansub bakteriyalar tomonidan chaqiriladigan zoonoz infeksion kasallik bo'lib, asosan kasallangan hayvonlar va ularning mahsulotlari orqali insonlarga yuqadi. Kasallik patogenezida bakteriyaning makrofaglar ichida yashab qolishi, limfa va retikuloendotelial tizimga tarqalishi hamda surunkali yallig'lanish jarayonlarini chaqirishi muhim rol o'ynaydi. Klinik jihatdan uzoq davom etuvchi isitma, intoksikatsiya va turli organlar zararlanishi bilan kechadi. Diagnostikada serologik reaksiyalar (Wright, Rose Bengal, ELISA) va molekulyar usul (PCR) asosiy ahamiyatga ega. Erta tashxis kasallik asoratlarini kamaytirishda muhim hisoblanadi.
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