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Botulizm: etiologiyasi, patogenezi va klinikasi

Authors

  • Kholmurodov Inoyatullo Ismatulloyevich

    Termiz University of Economics and Service, Head of the Department of Medical Preventive Sciences
    Author

  • Qo'ldoshev Ozodbek Ortiq oʻgʻli

    Student at Termez University of Economics and Service
    Author

Keywords:

Botulism, Clostridium botulinum, botulinum toxin, paralysis, neurotoxin, intoxication, neuromuscular transmission, canned food, respiratory failure

Abstract

Botulism is a severe toxic-infectious disease caused by botulinum toxin produced by Clostridium botulinum. It affects the neuromuscular transmission system, leading to flaccid paralysis. The main route of infection is the consumption of contaminated or improperly preserved food. In pathogenesis, the toxin blocks the release of acetylcholine at nerve endings. Clinically, it presents with blurred vision, difficulty in swallowing and speaking, muscle weakness, and respiratory failure.

References

1. Jawetz, Melnick & Adelberg‘s Medical Microbiology. 28th Edition. McGraw-Hill Education.

2. Murray, Rosenthal & Pfaller. Medical Microbiology. 9th Edition. Elsevier.

3. Mandell, Douglas, and Bennett‘s Principles and Practice of Infectious Diseases. 9th Edition. Elsevier.

4. Brooks G. F. et al. Jawetz Medical Microbiology.

5. WHO (World Health Organization). Botulism Fact Sheet and Guidelines. Geneva.

6. CDC (Centers for Disease Control and Prevention). Botulism: Clinical Overview and

Treatment Guidelines.

7. O'zbekiston Respublikasi Tibbiyot oliy ta‘lim muassasalari uchun Mikrobiologiya darsliklari.

8. Zambon, A. Clinical Infectious Diseases: Botulism Review Articles.

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Published

2026-04-11

Issue

Vol. 2 No. 4 (2026): Progress spectrum

Section

Articles