Tuberkulyozni davolashda lokal (mahalliy) yetkazib berish tizimlarining ahamiyati
Keywords:
Туберкулез, противотуберкулезные препараты, локальная доставка, наночастицы, биодоступность, ингаляция, лекарственная устойчивостьAbstract
This article analyzes the limitations of systemic use of anti-tuberculosis drugs and the advantages of local delivery methods in the treatment of tuberculosis. The deep penetration of tuberculosis mycobacteria into lung tissue and the increase in drug resistance remain a serious problem for global health. The article examines the mechanisms of drug delivery directly to the affected organ through nanoparticles, liposomes, and inhalation therapy. Local delivery methods allow increasing the drug's bioavailability, reducing systemic side effects, and shortening the treatment duration. Research results indicate that new delivery systems have high efficacy in treating multidrug-resistant tuberculosis (MDR-TB) forms.
References
1. Jahon Sog'liqni Saqlash Tashkiloti. Global Tuberculosis Report 2023. – Geneva: WHO, 2023. – P. 15-20.
2. Grinstaff M.W., Colson Y.L. New approaches for the treatment of tuberculosis. – New York: Springer, 2021. – P. 45-48.
3. O'zbekiston Respublikasi Sog'liqni Saqlash Vazirligi. Sil kasalligini aniqlash va davolash milliy protokollari. – Toshkent: Tibbiyot nashriyoti, 2022. – B. 34.
4. Singh U., Van Der Meeren A. Inhalation therapy for tuberculosis: A review of current status. – London: Journal of Drug Delivery, 2020. – Vol. 12. – P. 112-115.
5. Pandey R., Khuller G.K. Nanotechnology based drug delivery systems for tuberculosis. – India: Indian Journal of Medical Research, 2019. – Vol. 15. – P. 89-93.
6. Xasanov A., Karimov B. Zamonaviy tibbiyotda innovatsion dorilarni yetkazish tizimlari. – Toshkent: Osiyo Xalqaro Universiteti xabarnomasi, 2023. – 2-son. – B. 56-60.
